TFCP2L1

Across TCGA cell cohorts, TFCP2L1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TFCP2L1-associated genes across cancer lineages are SLC7A14, LGALS7B, and FAM205A. Each is linked with TFCP2L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TFCP2L1-to-partner and partner-to-TFCP2L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC7A14 grouped by TFCP2L1-low versus TFCP2L1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFCP2L1→partner) and Y-score (partner→TFCP2L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC7A14 →	+0.004	+3.475	<.001	.006	3	1
BLOOD_Leukemia	LGALS7B →	+0.158	+3.339	.001	.006	3	1
LARGE_INTESTINE	FAM205A →	+0.034	+4.614	<.001	.002	3	1
LUNG_SCLC	MAGEB18 →	+0.018	+4.269	<.001	.005	3	1
BLOOD_Leukemia	GADL1 →	+0.882	+3.569	<.001	.007	2	1
LARGE_INTESTINE	TKTL2 →	+0.053	+4.187	<.001	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SLC7A14 by TFCP2L1 expression — BLOOD_Leukemia

Explore this box plot interactively →