TFCP2

Across TCGA patient cohorts, TFCP2 mutation is significantly associated with the RNA expression of many other genes, with 2,036 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFCP2-associated genes across cancer lineages are RNU4-59P, CPLX3, and RNU6-182P. Each is linked with TFCP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TFCP2-to-partner and partner-to-TFCP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-59P grouped by TFCP2-low versus TFCP2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFCP2→partner) and Y-score (partner→TFCP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU4-59P →	+0.463	+5.655	<.001	.004	3	3
CESC	CPLX3 →	+0.010	+4.342	<.001	.007	3	3
LIHC	RNU6-182P →	+0.237	+4.894	<.001	.004	3	2
LIHC	TTTY25P →	+0.123	+3.964	<.001	.005	3	2
UCEC	C17orf98 →	+0.336	+2.237	.001	<.001	3	2
LIHC	RNU6-522P →	+0.195	+5.584	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,036 associations by consensus.

RNU4-59P by TFCP2 expression — HNSC

Explore this box plot interactively →