TFCP2

Across TCGA cell cohorts, TFCP2 mutation is significantly associated with the mutation status of many other genes, with 2,365 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TFCP2-associated genes across cancer lineages are FRAS1, UNC45B, and ASXL3. Each is linked with TFCP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TFCP2-to-partner and partner-to-TFCP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FRAS1 grouped by TFCP2-low versus TFCP2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFCP2→partner) and Y-score (partner→TFCP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FRAS1 →	+3.329	+4.562	.003	.003	1	3
SOFT_TISSUE	UNC45B →	+5.066	+4.502	.007	.007	1	3
SOFT_TISSUE	ASXL3 →	+3.329	+4.562	.003	.003	1	3
SOFT_TISSUE	MARCHF4 →	+5.066	+4.502	.007	.007	1	3
SOFT_TISSUE	ROBO3 →	+5.066	+4.502	.007	.007	1	3
SOFT_TISSUE	NSD1 →	+5.066	+4.502	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,365 associations by consensus.

FRAS1 by TFCP2 expression — SOFT_TISSUE

Explore this box plot interactively →