TFB1M

Across TCGA pan-cancer cohorts, TFB1M mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TFB1M data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TFB1M mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TFB1M expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where TFB1M mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	1.000	0.605	.006	12	view →
LUAD	DFS	Tertile	II,III,IV	0.960	0.779	.011	6	view →
CCRCC	DFS	Median	II,III,IV	0.469	0.766	.011	5	view →
HNSC	DFS	Median	All	0.984	0.920	.045	2	view →
GBM	DFS	Median	All	0.805	0.557	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TFB1M–LSCC (OS)

Open the LSCC breakdown →