TFAP4

Across TCGA pan-cancer cohorts, TFAP4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TFAP4 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TFAP4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TFAP4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, LIHC, and STAD are the cancer types where TFAP4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.158	0.835	<.001	30	view →
LIHC	OS	Median	All	0.010	0.784	<.001	24	view →
STAD	OS	Median	IV	0.001	0.544	<.001	18	view →
UCEC	DFS	Median	II,III,IV	1.000	0.440	.022	14	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TFAP4–LUAD (OS)

Open the LUAD breakdown →