TFAP4

Across TCGA pan-cancer cohorts, TFAP4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TFAP4 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TFAP4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TFAP4 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

UCEC, GBM, and LUAD are the cancer types where TFAP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.550	0.871	.022	6	view →
GBM	OS	Quartile	All	1.000	0.416	.001	5	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.435	.014	5	view →
CCRCC	DFS	Tertile	All	0.873	1.000	.016	4	view →
PDAC	DFS	Median	III,IV	0.537	0.977	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TFAP4–UCEC (DFS)

Open the UCEC breakdown →