TFAP4

Across TCGA patient cohorts, TFAP4 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFAP4-associated genes across cancer lineages are eIF4E, EGFR_pY1068, and ERK2. Each is linked with TFAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TFAP4-to-partner and partner-to-TFAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TFAP4-low versus TFAP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP4→partner) and Y-score (partner→TFAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.226	+3.321	.011	.010	3	2
UCEC	EGFR_pY1068 →	-0.214	-2.222	.045	.011	3	1
UCEC	ERK2 →	+0.174	+1.700	.033	.044	3	1
UCEC	Ku80 →	+0.326	+2.235	.001	.006	3	1
UCEC	MEK1 →	+0.491	+3.584	.001	.002	3	1
UCEC	Notch1 →	+0.171	+2.906	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

eIF4E by TFAP4 expression — UCEC

Explore this box plot interactively →