TFAP4

Across TCGA cell cohorts, TFAP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,443 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TFAP4-associated GO terms across cancer lineages are Host-mediated activation of viral transcription, Nucleosome disassembly, and Protein-DNA complex disassembly. Each is linked with TFAP4 in more than 17 cancer types. Because this analysis shows association rather than direction, both TFAP4-to-partner and partner-to-TFAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Host-mediated activation of viral transcription grouped by TFAP4-low versus TFAP4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP4→partner) and Y-score (partner→TFAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Host-mediated activation of viral transcription →	+0.141	+1.396	<.001	<.001	3	18
BONE	Nucleosome disassembly →	+0.179	+1.280	<.001	<.001	3	16
BONE	Protein-DNA complex disassembly →	+0.176	+1.484	<.001	<.001	3	16
BONE	DNA strand elongation involved in DNA replication →	+0.255	+1.900	<.001	<.001	3	16
BONE	rRNA pseudouridine synthesis →	+0.125	+1.288	<.001	<.001	3	16
BONE	Cell cycle DNA replication initiation →	+0.204	+1.375	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,443 associations by consensus.

Host-mediated activation of viral transcription by TFAP4 expression — BONE

Explore this box plot interactively →