TFAP2E

Across TCGA pan-cancer cohorts, TFAP2E mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TFAP2E’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TFAP2E mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TFAP2E is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and OV are the cancer types where TFAP2E tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TFAP2E mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.255	<.001	11	view →
LUAD	All	All	−0.583	<.001	7	view →
OV	All	All	−1.418	.027	2	view →
CCRCC	Male	All	+0.432	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TFAP2E–COAD

Open the COAD breakdown →