TFAP2E

Across TCGA patient cohorts, TFAP2E mutation is significantly associated with the RNA expression of many other genes, with 823 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFAP2E-associated genes across cancer lineages are BNIP3P19, KRTAP10-7, and GAK. Each is linked with TFAP2E in more than 1 cancer types. Because this analysis shows association rather than direction, both TFAP2E-to-partner and partner-to-TFAP2E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP3P19 grouped by TFAP2E-low versus TFAP2E-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP2E→partner) and Y-score (partner→TFAP2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	BNIP3P19 →	+0.109	+5.108	.007	.008	3	1
LIHC	KRTAP10-7 →	+0.021	+5.186	<.001	.007	3	1
UCEC	GAK →	+0.373	+2.724	.002	.003	3	1
UCEC	EDC3 →	+0.315	+3.354	.006	.005	3	1
UCEC	LSMEM2 →	+0.310	+3.370	<.001	.006	3	1
UCEC	TMEM150B →	+0.708	+3.708	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 823 associations by consensus.

BNIP3P19 by TFAP2E expression — LIHC

Explore this box plot interactively →