TFAP2E

Across TCGA cell cohorts, TFAP2E mutation is significantly associated with the mutation status of many other genes, with 2,076 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TFAP2E-associated genes across cancer lineages are GRIK3, ANKS1B, and ALPK3. Each is linked with TFAP2E in more than 2 cancer types. Because this analysis shows association rather than direction, both TFAP2E-to-partner and partner-to-TFAP2E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRIK3 grouped by TFAP2E-low versus TFAP2E-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP2E→partner) and Y-score (partner→TFAP2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GRIK3 →	+4.429	+5.247	.005	.005	1	3
BLOOD_Lymphoma	ANKS1B →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	ALPK3 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	NCOR1 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	ZNF184 →	+4.429	+5.247	.005	.005	1	2
LUNG_NSCLC_LUAD	CCDC50 →	+4.187	+5.000	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,076 associations by consensus.

GRIK3 by TFAP2E expression — BLOOD_Lymphoma

Explore this box plot interactively →