TFAP2E

Across TCGA cell cohorts, TFAP2E mutation is significantly associated with the drug of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TFAP2E-associated genes across cancer lineages are LMB_AB3, 630600, and CD532. Each is linked with TFAP2E in more than 1 cancer types. Because this analysis shows association rather than direction, both TFAP2E-to-partner and partner-to-TFAP2E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LMB_AB3 grouped by TFAP2E-low versus TFAP2E-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP2E→partner) and Y-score (partner→TFAP2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LMB_AB3 →	+0.442	+2.649	.012	.046	3	1
LARGE_INTESTINE	630600 →	+0.631	+2.649	.043	.046	3	1
LARGE_INTESTINE	CD532 →	+0.492	+2.652	.013	.045	3	1
LARGE_INTESTINE	IAP_5620 →	+0.397	+2.649	.031	.046	2	1
LARGE_INTESTINE	Oxaliplatin →	+0.613	+2.649	.020	.046	2	1
LARGE_INTESTINE	TL-2-105 →	+0.453	+2.652	.020	.045	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

LMB_AB3 by TFAP2E expression — LARGE_INTESTINE

Explore this box plot interactively →