TFAP2C

Across TCGA pan-cancer cohorts, TFAP2C mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TFAP2C data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TFAP2C mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TFAP2C expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and LSCC are the cancer types where TFAP2C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	1.000	0.365	.016	28	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.881	.009	12	view →
LSCC	OS	Tertile	II,III,IV	0.933	0.533	.012	6	view →
LUAD	OS	Median	All	0.497	1.000	.007	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TFAP2C–UCEC (OS)

Open the UCEC breakdown →