TFAP2C

Across TCGA pan-cancer cohorts, TFAP2C mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of TFAP2C’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where TFAP2C mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TFAP2C is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

LSCC, CCRCC, and LUAD are the cancer types where TFAP2C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TFAP2C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+0.747	<.001	7	view →
CCRCC	All	All	+0.495	.001	3	view →
LUAD	All	All	−0.268	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

TFAP2C–LSCC

Open the LSCC breakdown →