TFAP2C

Across TCGA patient cohorts, TFAP2C mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFAP2C-associated genes across cancer lineages are eIF4E, MSH6, and p27_pT157. Each is linked with TFAP2C in more than 1 cancer types. Because this analysis shows association rather than direction, both TFAP2C-to-partner and partner-to-TFAP2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TFAP2C-low versus TFAP2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP2C→partner) and Y-score (partner→TFAP2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.224	+3.459	.008	.005	3	2
UCEC	MSH6 →	-0.529	-2.321	<.001	.033	3	2
UCEC	p27_pT157 →	-0.050	-1.906	.030	.016	3	2
UCEC	P-Cadherin →	-0.149	-2.311	.010	.034	3	2
UCEC	ATM →	-0.588	-1.906	.001	.016	3	2
UCEC	14-3-3_beta →	-0.096	-3.295	.017	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eIF4E by TFAP2C expression — UCEC

Explore this box plot interactively →