TFAP2C

Across TCGA cell cohorts, TFAP2C mutation is significantly associated with the drug of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TFAP2C-associated genes across cancer lineages are Bromosporine, KRAS (G12C) Inhibitor-12, and GSK626616AC. Each is linked with TFAP2C in more than 1 cancer types. Because this analysis shows association rather than direction, both TFAP2C-to-partner and partner-to-TFAP2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bromosporine grouped by TFAP2C-low versus TFAP2C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP2C→partner) and Y-score (partner→TFAP2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Bromosporine →	+0.341	+2.649	.048	.046	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.724	+2.646	.003	.047	3	1
LARGE_INTESTINE	GSK626616AC →	+0.340	+2.777	.033	.038	2	1
LARGE_INTESTINE	CP466722 →	+0.414	+2.652	.036	.045	1	1
LARGE_INTESTINE	GSK2256098C →	+0.359	+2.906	.019	.033	1	1
LARGE_INTESTINE	Teniposide →	+0.808	+2.649	.001	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Bromosporine by TFAP2C expression — LARGE_INTESTINE

Explore this box plot interactively →