TFAP2B

Across TCGA patient cohorts, TFAP2B mutation is significantly associated with the RNA expression of many other genes, with 2,982 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFAP2B-associated genes across cancer lineages are IFI27L1, MRPL52, and AEN. Each is linked with TFAP2B in more than 2 cancer types. Because this analysis shows association rather than direction, both TFAP2B-to-partner and partner-to-TFAP2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFI27L1 grouped by TFAP2B-low versus TFAP2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP2B→partner) and Y-score (partner→TFAP2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IFI27L1 →	+0.380	+1.522	.001	.009	3	3
UCEC	MRPL52 →	+0.270	+2.004	.004	.007	3	3
UCEC	AEN →	+0.594	+1.653	<.001	<.001	3	3
UCEC	GTF2E2 →	+0.366	+1.840	<.001	<.001	3	3
UCEC	SELENOS →	+0.534	+2.290	<.001	<.001	3	3
UCEC	RNF145 →	+0.567	+1.468	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,982 associations by consensus.

IFI27L1 by TFAP2B expression — UCEC

Explore this box plot interactively →