TFAP2B

Across TCGA patient cohorts, TFAP2B mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFAP2B-associated genes across cancer lineages are ACVRL1, ATM, and PKC-delta_pS664. Each is linked with TFAP2B in more than 3 cancer types. Because this analysis shows association rather than direction, both TFAP2B-to-partner and partner-to-TFAP2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by TFAP2B-low versus TFAP2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP2B→partner) and Y-score (partner→TFAP2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.128	-2.209	.002	.009	3	3
UCEC	ATM →	-0.418	-1.700	.002	.001	3	3
COAD	PKC-delta_pS664 →	-0.162	-2.991	.019	.036	1	4
COAD	Rad50 →	-0.320	-2.991	.010	.036	3	2
COAD	ASNS →	+0.808	+3.008	<.001	.019	2	3
UCEC	EGFR_pY1068 →	-0.161	-1.362	.035	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

ACVRL1 by TFAP2B expression — UCEC

Explore this box plot interactively →