TFAP2B

Across TCGA cell cohorts, TFAP2B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,384 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TFAP2B-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Regulation of RNA splicing, and Regulation of mRNA processing. Each is linked with TFAP2B in more than 5 cancer types. Because this analysis shows association rather than direction, both TFAP2B-to-partner and partner-to-TFAP2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by TFAP2B-low versus TFAP2B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP2B→partner) and Y-score (partner→TFAP2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of double-strand break repair →	+0.080	+2.152	<.001	<.001	3	6
SOFT_TISSUE	Regulation of RNA splicing →	+0.054	+1.227	<.001	.001	3	6
SOFT_TISSUE	Regulation of mRNA processing →	+0.061	+1.246	<.001	.001	3	6
LUNG_SCLC	U2-type prespliceosome assembly →	+0.069	+1.303	.002	.007	3	5
LUNG_SCLC	Signal transduction in response to DNA damage →	+0.058	+1.501	<.001	.001	3	5
SOFT_TISSUE	RNA localization →	+0.062	+1.999	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,384 associations by consensus.

Positive regulation of double-strand break repair by TFAP2B expression — BONE

Explore this box plot interactively →