TFAP2B

Across TCGA cell cohorts, TFAP2B mutation is significantly associated with the drug of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TFAP2B-associated genes across cancer lineages are Lestaurtinib, SU11274, and GSK690693. Each is linked with TFAP2B in more than 1 cancer types. Because this analysis shows association rather than direction, both TFAP2B-to-partner and partner-to-TFAP2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lestaurtinib grouped by TFAP2B-low versus TFAP2B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAP2B→partner) and Y-score (partner→TFAP2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Lestaurtinib →	+0.510	+2.710	.041	.043	3	1
LARGE_INTESTINE	SU11274 →	+0.414	+2.874	.036	.021	3	1
LARGE_INTESTINE	GSK690693 →	+0.747	+2.710	.001	.027	3	1
LARGE_INTESTINE	CPI-613 →	+0.267	+2.807	.034	.044	3	1
LARGE_INTESTINE	CD532 →	+0.511	+2.874	.006	.021	3	1
LARGE_INTESTINE	HG-5-113-01 →	+0.329	+2.667	.036	.040	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Lestaurtinib by TFAP2B expression — LARGE_INTESTINE

Explore this box plot interactively →