TFAM

Across TCGA patient cohorts, TFAM RNA expression is significantly associated with the protein abundance of many other proteins, with 15,087 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TFAM-associated proteins across cancer lineages are MSH2, CCAR1, and DDX21. Each is linked with TFAM in more than 6 cancer types. Because this analysis shows association rather than direction, both TFAM-to-partner and partner-to-TFAM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TFAM versus MSH2 in GBM, with a Pearson correlation of 0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAM→partner) and Y-score (partner→TFAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MSH2 →	+0.401	+0.415	.001	<.001	3	7
GBM	CCAR1 →	+0.195	+0.408	.002	.001	3	7
LSCC	DDX21 →	+0.512	+0.609	<.001	<.001	3	7
OV	SNRPD2 →	+0.310	+0.448	.004	.002	3	7
OV	MPHOSPH10 →	+0.349	+0.529	.002	.002	3	6
GBM	ZNF638 →	+0.301	+0.577	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,087 associations by consensus.

TFAM vs MSH2 — GBM

Explore this scatter interactively →