TFAM

Across TCGA patient cohorts, TFAM mutation is significantly associated with the RNA expression of many other genes, with 1,246 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFAM-associated genes across cancer lineages are RNA5SP405, LINC02559, and KMT2B. Each is linked with TFAM in more than 2 cancer types. Because this analysis shows association rather than direction, both TFAM-to-partner and partner-to-TFAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP405 grouped by TFAM-low versus TFAM-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAM→partner) and Y-score (partner→TFAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP405 →	+0.228	+7.816	<.001	.008	3	3
CESC	LINC02559 →	+1.376	+6.342	<.001	.001	3	2
UCEC	KMT2B →	+0.525	+2.711	.001	.003	3	1
UCEC	DCP1A →	+0.694	+3.364	<.001	.004	3	1
UCEC	CWC25 →	+0.494	+3.512	.002	.002	3	1
UCEC	ZNHIT3 →	+0.502	+3.828	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,246 associations by consensus.

RNA5SP405 by TFAM expression — SKCM

Explore this box plot interactively →