TFAM

Across TCGA patient cohorts, TFAM mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFAM-associated genes across cancer lineages are eEF2, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with TFAM in more than 1 cancer types. Because this analysis shows association rather than direction, both TFAM-to-partner and partner-to-TFAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TFAM-low versus TFAM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAM→partner) and Y-score (partner→TFAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.436	+3.000	.008	.036	3	1
UCEC	EGFR_pY1068 →	-0.317	-3.321	.006	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.251	-3.459	.001	.005	3	1
UCEC	Ku80 →	+0.241	+2.598	.028	.006	3	1
UCEC	MEK1 →	+0.457	+2.321	.007	.034	3	1
UCEC	p27_pT198 →	+0.121	+3.321	.015	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

eEF2 by TFAM expression — UCEC

Explore this box plot interactively →