TFAM

Across TCGA cell cohorts, TFAM RNA expression is significantly associated with the go_rna of many other GO terms, with 3,876 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TFAM-associated GO terms across cancer lineages are DNA replication initiation, Lagging strand elongation, and DNA strand elongation. Each is linked with TFAM in more than 18 cancer types. Because this analysis shows association rather than direction, both TFAM-to-partner and partner-to-TFAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by TFAM-low versus TFAM-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TFAM→partner) and Y-score (partner→TFAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.172	+1.745	<.001	<.001	3	19
OVARY	Lagging strand elongation →	+0.156	+0.741	<.001	<.001	3	19
BONE	DNA strand elongation →	+0.204	+1.128	.001	<.001	3	18
OESOPHAGUS	DNA replication, removal of RNA primer →	+0.158	+0.830	<.001	<.001	3	18
SOFT_TISSUE	Spindle elongation →	+0.239	+1.127	<.001	<.001	3	18
BONE	'de novo' IMP biosynthetic process →	+0.136	+0.863	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,876 associations by consensus.

DNA replication initiation by TFAM expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →