Across TCGA pan-cancer cohorts, TEX9 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of TEX9’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LSCC), where TEX9 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TEX9 is over-expressed in tumor, although a few such as LSCC show the opposite, repressed pattern.
LSCC are the cancer types where TEX9 tumor–normal differential expression is most reproducible.