TEX9

Across TCGA patient cohorts, TEX9 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEX9-associated genes across cancer lineages are p62 Lck ligand, 14-3-3_beta, and eIF4E. Each is linked with TEX9 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEX9-to-partner and partner-to-TEX9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by TEX9-low versus TEX9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEX9→partner) and Y-score (partner→TEX9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.563	+3.331	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.093	-2.973	.040	.035	3	1
UCEC	eIF4E →	+0.209	+3.169	.028	.019	3	1
UCEC	MEK1 →	+0.494	+2.700	.002	.006	3	1
UCEC	Notch1 →	+0.183	+2.700	.003	.006	3	1
UCEC	p27_pT198 →	+0.102	+2.000	.035	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

p62 Lck ligand by TEX9 expression — UCEC

Explore this box plot interactively →