TEX55

Across TCGA patient cohorts, TEX55 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEX55-associated genes across cancer lineages are AMPK_alpha, Bax, and 14-3-3_beta. Each is linked with TEX55 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEX55-to-partner and partner-to-TEX55 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMPK_alpha grouped by TEX55-low versus TEX55-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEX55→partner) and Y-score (partner→TEX55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	AMPK_alpha →	+0.195	+2.816	.031	.036	3	2
SKCM	Bax →	-0.345	-3.321	.003	.010	3	2
UCEC	14-3-3_beta →	-0.111	-2.295	.006	.033	3	2
UCEC	JNK2 →	+0.252	+2.415	.001	.003	3	2
UCEC	N-Ras →	-0.165	-2.401	<.001	.003	3	2
UCEC	Annexin-1 →	+0.773	+2.415	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

AMPK_alpha by TEX55 expression — LUSC

Explore this box plot interactively →