TEX55

Across TCGA cell cohorts, TEX55 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TEX55-associated genes across cancer lineages are CYP7A1, RBMY1A1, and OR2T7. Each is linked with TEX55 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEX55-to-partner and partner-to-TEX55 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP7A1 grouped by TEX55-low versus TEX55-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEX55→partner) and Y-score (partner→TEX55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CYP7A1 →	+0.015	+4.285	<.001	.006	3	2
BLOOD_Lymphoma	RBMY1A1 →	+0.039	+5.209	<.001	.005	3	1
LUNG_SCLC	OR2T7 →	+0.005	+4.643	<.001	.004	3	1
LARGE_INTESTINE	BPIFB6 →	+0.025	+5.022	<.001	.002	3	1
LARGE_INTESTINE	NUPR2 →	+0.376	+4.273	<.001	.006	3	1
LARGE_INTESTINE	F11 →	+0.057	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

CYP7A1 by TEX55 expression — BLOOD_Leukemia

Explore this box plot interactively →