TEX49

Across TCGA pan-cancer cohorts, TEX49 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of TEX49’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where TEX49 RNA is repressed in tumor relative to normal tissue. In most cancer types TEX49 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and KIRC are the cancer types where TEX49 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TEX49 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	All	−0.453	<.001	8	view →
LUAD	Female	II,III,IV	−0.526	<.001	6	view →
KIRC	All	II,III,IV	−0.037	.008	3	view →
CHOL	Male	All	+0.088	.012	2	view →
KIRP	All	III,IV	+0.066	.020	2	view →
ESCA	All	All	−0.783	.020	1	view →
KICH	All	II,III,IV	−0.063	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

TEX49–LUSC

Open the LUSC breakdown →