TEX261

Across TCGA pan-cancer cohorts, TEX261 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TEX261’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TEX261 RNA is repressed in tumor relative to normal tissue. In most cancer types TEX261 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and LIHC are the cancer types where TEX261 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TEX261 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.317	<.001	11	view →
HNSC	All	III,IV	+0.692	<.001	11	view →
LIHC	Female	II,III,IV	+1.051	<.001	8	view →
STAD	Male	II,III,IV	+0.969	<.001	6	view →
BLCA	Female	III,IV	+0.917	<.001	6	view →
KICH	Male	All	−0.765	<.001	6	view →
CHOL	Male	All	+1.583	<.001	5	view →
LUSC	All	All	+0.284	<.001	5	view →
KIRC	Female	All	+0.317	.010	3	view →
COAD	Male	II,III,IV	+0.223	.015	3	view →
ESCA	Female	All	+0.726	.003	2	view →
READ	All	All	+0.313	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TEX261–THCA

Open the THCA breakdown →