TEX2

Across TCGA pan-cancer cohorts, TEX2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TEX2 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TEX2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TEX2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

PDAC, LSCC, and UCEC are the cancer types where TEX2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	III,IV	0.399	0.991	.004	9	view →
LSCC	DFS	Median	All	0.559	0.944	.005	6	view →
UCEC	OS	Median	II,III,IV	1.000	0.638	.014	4	view →
HNSC	DFS	Quartile	II,III,IV	0.912	0.680	.028	2	view →
LUAD	DFS	Quartile	All	0.911	0.505	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TEX2–PDAC (OS)

Open the PDAC breakdown →