TEX2

Across TCGA pan-cancer cohorts, TEX2 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TEX2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TEX2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TEX2 is over-expressed in tumor, although a few such as LUAD and PDAC show the opposite, repressed pattern.

LUAD, HNSC, and PDAC are the cancer types where TEX2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TEX2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−0.226	<.001	8	view →
HNSC	All	III,IV	+0.193	.002	8	view →
PDAC	Male	All	−0.546	<.001	7	view →
LSCC	All	II,III,IV	−0.118	.005	5	view →
CCRCC	All	II,III,IV	+0.223	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TEX2–LUAD

Open the LUAD breakdown →