TEX2

Across TCGA patient cohorts, TEX2 mutation is significantly associated with the RNA expression of many other genes, with 4,853 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEX2-associated genes across cancer lineages are RNU6-155P, UTP11, and SNORD66. Each is linked with TEX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TEX2-to-partner and partner-to-TEX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-155P grouped by TEX2-low versus TEX2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEX2→partner) and Y-score (partner→TEX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-155P →	+0.289	+4.368	<.001	.001	3	4
SKCM	UTP11 →	+0.623	+2.719	<.001	.003	3	3
SKCM	SNORD66 →	+0.255	+2.783	<.001	<.001	3	3
UCEC	BUB3 →	+0.526	+1.874	<.001	<.001	3	3
UCEC	C9orf64 →	+0.649	+1.917	<.001	<.001	3	3
UCEC	TRABD →	+0.482	+2.119	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,853 associations by consensus.

RNU6-155P by TEX2 expression — HNSC

Explore this box plot interactively →