TEX2

Across TCGA patient cohorts, TEX2 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEX2-associated genes across cancer lineages are Notch1, Caspase-7-cleavedD198, and eEF2. Each is linked with TEX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TEX2-to-partner and partner-to-TEX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TEX2-low versus TEX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEX2→partner) and Y-score (partner→TEX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.186	+1.999	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.619	+2.824	<.001	.034	3	2
UCEC	eEF2 →	+0.232	+1.584	.032	.032	3	2
UCEC	EGFR_pY1068 →	-0.179	-1.514	.018	.014	3	2
UCEC	mTOR_pS2448 →	-0.104	-1.228	.021	.041	3	2
UCEC	p21 →	+0.126	+1.713	.030	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Notch1 by TEX2 expression — UCEC

Explore this box plot interactively →