TEX2

Across TCGA cell cohorts, TEX2 mutation is significantly associated with the RNA expression of many other genes, with 201 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TEX2-associated genes across cancer lineages are SLC10A2, GZMK, and HTR3D. Each is linked with TEX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TEX2-to-partner and partner-to-TEX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC10A2 grouped by TEX2-low versus TEX2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEX2→partner) and Y-score (partner→TEX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SLC10A2 →	+0.016	+4.643	<.001	.008	3	3
BLOOD_Leukemia	GZMK →	+0.299	+2.300	.006	.006	3	2
BLOOD_Lymphoma	HTR3D →	+0.012	+4.662	<.001	.003	3	2
LUNG_SCLC	OR11H1 →	+0.075	+4.044	<.001	.009	3	2
LUNG_NSCLC_LUSC	GZMH →	+0.036	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CRYGD →	+0.040	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 201 associations by consensus.

SLC10A2 by TEX2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →