TEX19

Across TCGA patient cohorts, TEX19 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TEX19-associated genes across cancer lineages are Ku80, A-Raf_pS299, and Fibronectin. Each is linked with TEX19 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEX19-to-partner and partner-to-TEX19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by TEX19-low versus TEX19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEX19→partner) and Y-score (partner→TEX19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.291	+2.183	.018	.035	3	1
SKCM	A-Raf_pS299 →	+0.174	+3.000	.034	.036	3	1
SKCM	Fibronectin →	-0.524	-3.000	.041	.036	3	1
SKCM	Bad_pS112 →	+0.250	+2.820	.018	.035	3	1
UCEC	Mre11 →	-0.118	-3.321	.008	.010	2	1
SKCM	PR →	-0.115	-3.000	.027	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Ku80 by TEX19 expression — UCEC

Explore this box plot interactively →