TEX101

Across TCGA patient cohorts, TEX101 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEX101-associated genes across cancer lineages are Ku80, PDCD4, and VHL. Each is linked with TEX101 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEX101-to-partner and partner-to-TEX101 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by TEX101-low versus TEX101-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEX101→partner) and Y-score (partner→TEX101) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.248	+3.009	.045	.019	3	2
UCEC	PDCD4 →	-0.690	-3.160	.005	.019	3	1
UCEC	VHL →	-0.997	-3.000	.005	.036	3	1
UCEC	Caspase-8 →	-0.261	-3.321	.047	.010	3	1
UCEC	c-Met_pY1235 →	+0.097	+3.321	.012	.010	3	1
UCEC	p62 Lck ligand →	+0.523	+2.817	.002	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Ku80 by TEX101 expression — UCEC

Explore this box plot interactively →