Across TCGA patient cohorts, TET3 mutation is significantly associated with the RNA expression of many other genes, with 5,398 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TET3-associated genes across cancer lineages are ZNF667-AS1, ITPK1, and BNIP1. Each is linked with TET3 in more than 4 cancer types. Because this analysis shows association rather than direction, both TET3-to-partner and partner-to-TET3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TET3→partner) and Y-score (partner→TET3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF667-AS1 →	-1.019	-1.367	<.001	<.001	3	4
UCEC	ITPK1 →	+0.284	+1.669	.002	<.001	3	4
UCEC	BNIP1 →	+0.358	+2.137	<.001	<.001	3	4
UCEC	FXYD6 →	-0.569	-1.378	.004	.007	3	4
UCEC	GPR173 →	-0.688	-1.503	<.001	<.001	3	4
STAD	C1GALT1C1L →	-0.879	-3.568	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,398 associations by consensus.

Exploration

TET3 survival (RNA) · tumor vs normal (RNA) · all TET3 data types