TET2

Across TCGA patient cohorts, TET2 protein abundance is significantly associated with the RNA expression of many other genes, with 660 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TET2-associated genes across cancer lineages are COL4A2-AS1, NDRG1, and TLE6. Each is linked with TET2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TET2-to-partner and partner-to-TET2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TET2 versus COL4A2-AS1 in HNSC, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TET2→partner) and Y-score (partner→TET2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	COL4A2-AS1 →	-0.941	-1.010	.009	.008	3	2
UCEC	NDRG1 →	+1.485	+0.365	.003	.004	3	1
UCEC	TLE6 →	+1.042	+0.383	.002	.001	3	1
UCEC	SLC1A5 →	+0.987	+0.278	.007	.008	3	1
UCEC	TRDMT1 →	-0.817	-0.325	.003	.007	3	1
UCEC	GCLC →	-0.651	-0.347	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 660 associations by consensus.

TET2 vs COL4A2-AS1 — HNSC

Explore this scatter interactively →