TET2-AS1

Across TCGA pan-cancer cohorts, TET2-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TET2-AS1 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher TET2-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TET2-AS1 expression acts as an unfavorable survival marker, although some lineages such as CESC and SKCM show a favorable association.

CESC, SKCM, and UCEC are the cancer types where TET2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.873	0.719	<.001	104	view →
SKCM	OS	Median	III,IV	0.965	0.736	<.001	39	view →
UCEC	DFS	Tertile	IV	0.206	0.667	<.001	36	view →
THYM	OS	Quartile	All	0.893	0.989	.006	32	view →
STAD	OS	Quartile	II,III,IV	0.615	0.422	.009	31	view →
LUAD	DFS	Quartile	II,III,IV	0.628	0.343	.011	28	view →
READ	DFS	Tertile	IV	0.289	0.671	.007	21	view →
TGCT	DFS	Tertile	II,III,IV	0.678	0.996	.014	18	view →
OV	DFS	Tertile	IV	0.227	0.459	.014	10	view →
PRAD	OS	Median	All	0.977	1.000	.014	10	view →
UVM	OS	Tertile	II,III,IV	1.000	0.519	.039	9	view →
PAAD	OS	Median	All	0.567	0.350	.019	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TET2-AS1–CESC (OS)

Open the CESC breakdown →