TET1

Across TCGA patient cohorts, TET1 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,316 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TET1-associated proteins across cancer lineages are PBRM1, PHC1_S664, and HDAC2. Each is linked with TET1 in more than 5 cancer types. Because this analysis shows association rather than direction, both TET1-to-partner and partner-to-TET1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TET1 versus PBRM1 in GBM, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TET1→partner) and Y-score (partner→TET1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PBRM1 →	+0.282	+0.567	<.001	<.001	3	6
HNSC	PHC1_S664 →	+0.774	+0.883	<.001	<.001	3	6
GBM	HDAC2 →	+0.406	+0.821	<.001	<.001	3	6
GBM	MBD3 →	+0.499	+0.667	<.001	<.001	3	6
LSCC	TNPO2 →	+0.205	+0.471	.001	.001	3	6
UCEC	PSMB10 →	-0.580	-0.516	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,316 associations by consensus.

TET1 vs PBRM1 — GBM

Explore this scatter interactively →