TET1

Across TCGA patient cohorts, TET1 mutation is significantly associated with the RNA expression of many other genes, with 5,710 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TET1-associated genes across cancer lineages are PTTG1, RHBDD3, and GBP5. Each is linked with TET1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TET1-to-partner and partner-to-TET1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTTG1 grouped by TET1-low versus TET1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TET1→partner) and Y-score (partner→TET1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PTTG1 →	+0.520	+1.660	.001	.003	3	5
BRCA	RHBDD3 →	+0.614	+3.483	.001	.002	3	5
BRCA	GBP5 →	+1.100	+3.325	.007	.005	3	4
UCEC	C19orf47 →	+0.259	+1.501	.003	<.001	3	4
UCEC	CRK →	+0.337	+1.809	<.001	<.001	3	4
UCEC	TSR1 →	+0.482	+1.788	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,710 associations by consensus.

PTTG1 by TET1 expression — UCEC

Explore this box plot interactively →