TET1

Across TCGA cell cohorts, TET1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,333 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TET1-associated GO terms across cancer lineages are Positive regulation of DNA repair, Negative regulation of gene expression, epigenetic, and Regulation of DNA repair. Each is linked with TET1 in more than 15 cancer types. Because this analysis shows association rather than direction, both TET1-to-partner and partner-to-TET1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by TET1-low versus TET1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TET1→partner) and Y-score (partner→TET1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of DNA repair →	+0.072	+1.214	<.001	<.001	3	16
STOMACH	Negative regulation of gene expression, epigenetic →	+0.069	+0.874	<.001	<.001	3	16
BONE	Regulation of DNA repair →	+0.065	+0.818	<.001	<.001	3	16
BONE	Nucleosome organization →	+0.151	+0.869	<.001	<.001	3	16
LUNG_SCLC	Protein-DNA complex organization →	+0.078	+1.063	<.001	<.001	3	15
BONE	Positive regulation of DNA metabolic process →	+0.072	+0.701	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,333 associations by consensus.

Positive regulation of DNA repair by TET1 expression — STOMACH

Explore this box plot interactively →