TET1

Across TCGA cell cohorts, TET1 mutation is significantly associated with the RNA expression of many other genes, with 501 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TET1-associated genes across cancer lineages are PLA2G12B, SPATA48, and METTL16. Each is linked with TET1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TET1-to-partner and partner-to-TET1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLA2G12B grouped by TET1-low versus TET1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TET1→partner) and Y-score (partner→TET1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PLA2G12B →	+0.017	+3.256	.006	.001	3	2
BLOOD_Leukemia	SPATA48 →	+0.573	+3.029	.001	.002	3	2
LARGE_INTESTINE	METTL16 →	+0.405	+1.850	.009	.006	3	2
LARGE_INTESTINE	INTS14 →	+0.403	+3.169	.003	.009	3	2
LARGE_INTESTINE	WRAP53 →	+0.499	+2.584	.001	.002	3	2
LARGE_INTESTINE	MRPL17 →	+0.360	+1.850	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 501 associations by consensus.

PLA2G12B by TET1 expression — BLOOD_Leukemia

Explore this box plot interactively →