TET1

Across TCGA cell cohorts, TET1 mutation is significantly associated with the mutation status of many other genes, with 5,924 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TET1-associated genes across cancer lineages are TRAPPC8, HERC1, and JMJD1C. Each is linked with TET1 in more than 6 cancer types. Because this analysis shows association rather than direction, both TET1-to-partner and partner-to-TET1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAPPC8 grouped by TET1-low versus TET1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TET1→partner) and Y-score (partner→TET1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TRAPPC8 →	+5.307	+4.651	<.001	<.001	1	7
SKIN	HERC1 →	+2.313	+3.282	.007	.007	1	6
CNS	JMJD1C →	+4.044	+5.000	.008	.008	1	5
KIDNEY	MDN1 →	+3.201	+3.491	.008	.008	1	5
LARGE_INTESTINE	LAMA3 →	+1.479	+1.643	.004	.004	1	5
BLOOD_Leukemia	MYCBP2 →	+1.845	+2.037	.008	.008	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,924 associations by consensus.

TRAPPC8 by TET1 expression — SOFT_TISSUE

Explore this box plot interactively →