TESPA1

Across TCGA patient cohorts, TESPA1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TESPA1-associated genes across cancer lineages are FASN, EGFR_pY1068, and eIF4E. Each is linked with TESPA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TESPA1-to-partner and partner-to-TESPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by TESPA1-low versus TESPA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TESPA1→partner) and Y-score (partner→TESPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.544	+2.247	<.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.296	-2.700	.001	.005	3	2
UCEC	eIF4E →	+0.161	+2.335	.037	.018	3	2
UCEC	FoxM1 →	+0.295	+2.736	.001	<.001	3	2
UCEC	MEK1 →	+0.541	+3.807	<.001	<.001	3	2
UCEC	p27_pT157 →	-0.044	-1.847	.038	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

FASN by TESPA1 expression — UCEC

Explore this box plot interactively →