TESPA1

Across TCGA cell cohorts, TESPA1 mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TESPA1-associated genes across cancer lineages are CBLIF, UBE3A, and GBE1. Each is linked with TESPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TESPA1-to-partner and partner-to-TESPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBLIF grouped by TESPA1-low versus TESPA1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TESPA1→partner) and Y-score (partner→TESPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CBLIF →	+0.019	+3.362	<.001	.007	3	1
LARGE_INTESTINE	UBE3A →	+0.570	+3.252	<.001	.002	3	1
LARGE_INTESTINE	GBE1 →	+0.646	+2.628	.003	.002	3	1
LARGE_INTESTINE	C2orf42 →	+0.416	+3.237	.009	.003	3	1
LARGE_INTESTINE	ZNF25 →	+0.467	+2.628	.002	.002	3	1
LARGE_INTESTINE	CLK3 →	+0.433	+3.829	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

CBLIF by TESPA1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →