TESK2

Across TCGA cell cohorts, TESK2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TESK2-associated genes across cancer lineages are IQCF5, NKX2-6, and TLE7. Each is linked with TESK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TESK2-to-partner and partner-to-TESK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by TESK2-low versus TESK2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TESK2→partner) and Y-score (partner→TESK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	2
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1
LARGE_INTESTINE	OR4F5 →	+0.024	+3.345	<.001	.007	3	1
LARGE_INTESTINE	FAM170A →	+0.120	+3.070	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

IQCF5 by TESK2 expression — BLOOD_Leukemia

Explore this box plot interactively →