TESK1

Across TCGA pan-cancer cohorts, TESK1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TESK1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TESK1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TESK1 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where TESK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	III,IV	0.295	0.938	.006	29	view →
PDAC	DFS	Median	II,III,IV	0.199	0.587	.023	27	view →
LUAD	DFS	Tertile	All	0.537	0.934	.008	3	view →
GBM	OS	Median	All	0.625	0.428	.028	2	view →
CCRCC	DFS	Median	All	0.872	0.662	.043	1	view →
HNSC	DFS	Median	All	0.643	0.936	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TESK1–LSCC (OS)

Open the LSCC breakdown →