TESK1

Across TCGA patient cohorts, TESK1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TESK1-associated genes across cancer lineages are c-Kit, Di-Ras3, and 14-3-3_beta. Each is linked with TESK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TESK1-to-partner and partner-to-TESK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by TESK1-low versus TESK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TESK1→partner) and Y-score (partner→TESK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Kit →	-0.241	-3.156	.014	.018	3	2
UCEC	Di-Ras3 →	-0.183	-3.308	.003	.009	3	2
UCEC	14-3-3_beta →	-0.102	-3.295	.017	.009	3	1
UCEC	MSH2 →	-0.414	-2.906	<.001	.001	3	1
UCEC	MSH6 →	-0.407	-3.169	.003	.018	3	1
UCEC	Myosin-IIa_pS1943 →	+0.213	+1.713	.014	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

c-Kit by TESK1 expression — UCEC

Explore this box plot interactively →